Interleukin-1 Receptor Antagonist Protein (IRAP) is a protein that is found naturally within the horse. It can be used as a joint treatment to combat inflammation, osteoarthritis, or degenerative joint disease in the horse. IRAP is acquired by harvesting blood from the patient (horse) and processed using special techniques to acquire serum that has a high concentration of this naturally occurring protein. The IRAP is then injected into the affected joint(s) of the horse. In a typical course of treatment, the IRAP is injected into the affected joint on three separate occasions in 1-2 week intervals. It can be repeated after the initial series depending on your horse’s response and need.